High expression of Musashi-2 indicates poor prognosis in adult B-cell acute lymphoblastic leukemia

Leuk Res. 2013 Aug;37(8):922-7. doi: 10.1016/j.leukres.2013.05.012. Epub 2013 Jun 4.

Abstract

Musashi-2 (MSI2) expression of 116 adult B-cells acute lymphoblastic leukemia (B-ALL) patients was measured by real-time PCR. Kaplan-Meier analysis showed that patients with high MSI2 expression had inferior overall survival (OS) (P=0.004), event free survival (EFS) (P=0.001) and relapse free survival (RFS) (P=0.018) in BCR-ABL-negative B-ALL. Multivariate models revealed that, besides WBC more than 30×10(9)/L and IK6 variant of IKZF1, high MSI2 expression was also an independent prognostic factor for adult BCR-ABL-negative B-ALL. Our data suggest that high MSI2 expression could indicate poor prognosis and facilitate risk and treatment stratification in adult BCR-ABL-negative B-ALL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • B-Lymphocytes / metabolism*
  • B-Lymphocytes / pathology
  • Female
  • Fusion Proteins, bcr-abl / genetics
  • Gene Expression Regulation, Leukemic*
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Prognosis
  • RNA-Binding Proteins / genetics*
  • RNA-Directed DNA Polymerase
  • Young Adult

Substances

  • MSI2 protein, human
  • RNA-Binding Proteins
  • Fusion Proteins, bcr-abl
  • RNA-Directed DNA Polymerase