Jump-starting the T cells in CLL

Blood. 2013 May 16;121(20):4016-7. doi: 10.1182/blood-2013-04-491787.

Abstract

In this issue of Blood, Shanafelt and colleagues demonstrate that T-cell immune synapse function can be increased in chronic lymphocytic leukemia (CLL), both by reducing tumor burden with immunochemotherapy and by lenalidomide.

Publication types

  • Comment

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Consolidation Chemotherapy*
  • Humans
  • Immunological Synapses / physiology*
  • Immunotherapy*
  • Lenalidomide
  • Leukemia, Lymphocytic, Chronic, B-Cell / therapy*
  • T-Lymphocytes / immunology*
  • Thalidomide / administration & dosage
  • Thalidomide / analogs & derivatives*

Substances

  • Thalidomide
  • Lenalidomide