Epidemiological and clinical complexity of amoxicillin-clavulanate-resistant Escherichia coli

J Clin Microbiol. 2013 Jul;51(7):2414-7. doi: 10.1128/JCM.00999-13. Epub 2013 May 1.

Abstract

Two hundred twelve patients with colonization/infection due to amoxicillin-clavulanate (AMC)-resistant Escherichia coli were studied. OXA-1- and inhibitor-resistant TEM (IRT)-producing strains were associated with urinary tract infections, while OXA-1 producers and chromosomal AmpC hyperproducers were associated with bacteremic infections. AMC resistance in E. coli is a complex phenomenon with heterogeneous clinical implications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Amoxicillin-Potassium Clavulanate Combination / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Bacteremia / epidemiology
  • Bacteremia / microbiology
  • Bacteremia / pathology
  • Child
  • Cross-Sectional Studies
  • Escherichia coli / drug effects*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / epidemiology*
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / pathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Urinary Tract Infections / epidemiology
  • Urinary Tract Infections / microbiology
  • Urinary Tract Infections / pathology
  • Young Adult
  • beta-Lactam Resistance*

Substances

  • Anti-Bacterial Agents
  • Amoxicillin-Potassium Clavulanate Combination