pH-controlled delivery of nanoparticles into tumor cells

Adv Healthc Mater. 2013 Nov;2(11):1435-9. doi: 10.1002/adhm.201300013. Epub 2013 Apr 8.

Abstract

Nanoparticles target tumor cells by pH-controlled means. Nanoparticles carry three synergistic delivery functions: 1) tumor tissue targeting by the EPR effect; 2) tumor cell targeting by pHLIP-mediated membrane-localization; and 3) tumor cell uptake by adsorptive-mediated endocytosis.

Keywords: gene delivery; nanoparticles; targeting acidity; tumor-targeting delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Membrane / metabolism
  • DNA / metabolism
  • Dendrimers / chemistry
  • Drug Delivery Systems*
  • Humans
  • Hydrogen-Ion Concentration
  • Mice
  • Nanoparticles / chemistry*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Peptides / chemistry
  • Plasmids / metabolism
  • Polyethylene Glycols
  • Polylysine / chemistry

Substances

  • Dendrimers
  • Peptides
  • Polylysine
  • Polyethylene Glycols
  • DNA