Severe infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus in infants: report of three cases and review of literature

Acta Paediatr. 2013 Jun;102(6):e284-7. doi: 10.1111/apa.12225. Epub 2013 Mar 28.

Abstract

We report three cases of severe infections in infants caused by Panton-Valentine leukocidin positive Staphylococcus aureus and evolved with a positive outcome. The literature of Panton-Valentine leukocidin positive Staphylococcus aureus infections in infants is reviewed.

Conclusion: Our findings suggest that a prompt identification of Panton-Valentine leukocidin positive Staphylococcus aureus and an appropriate therapy can reduce mortality and long-term sequelae. Further research is needed to specify features of Panton-Valentine leukocidin positive Staphylococcus aureus infections in infants.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acetamides / administration & dosage
  • Anti-Infective Agents / administration & dosage
  • Bacterial Toxins / metabolism*
  • Exotoxins / metabolism*
  • Female
  • Humans
  • Infant
  • Leukocidins / metabolism*
  • Linezolid
  • Male
  • Oxazolidinones / administration & dosage
  • Respiratory Insufficiency / microbiology
  • Retropharyngeal Abscess / microbiology
  • Staphylococcal Infections / metabolism
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / surgery
  • Staphylococcus aureus / metabolism*
  • Tomography, X-Ray Computed

Substances

  • Acetamides
  • Anti-Infective Agents
  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Oxazolidinones
  • Panton-Valentine leukocidin
  • Linezolid