Epidermal growth factor receptor expression in demented and aged human brain

Brain Res. 1990 Apr 2;512(2):347-52. doi: 10.1016/0006-8993(90)90647-t.

Abstract

Immunoreactivity to epidermal growth factor receptor (EGFR) was present in the brain vasculature of 13/13 demented elderly patients, but absent in 9/11 non-demented elderly patients. Of the two positive non-demented patients, one had significant Alzheimer's pathology and the other spinal carcinoma. Ultrastructurally, EGFR is localized to the lumenal surface of endothelial cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / metabolism*
  • Brain / blood supply
  • Brain / growth & development*
  • Brain / pathology
  • Dementia / metabolism*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / pathology
  • ErbB Receptors / metabolism*
  • ErbB Receptors / physiology
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged

Substances

  • ErbB Receptors