Alzheimer disease-like cellular phenotype of newborn granule neurons can be reversed in GSK-3β-overexpressing mice

Mol Psychiatry. 2013 Apr;18(4):395. doi: 10.1038/mp.2013.27.

Authors

M Llorens-Martín¹, A Fuster-Matanzo, C M Teixeira, J Jurado-Arjona, F Ulloa, J Defelipe, A Rábano, F Hernández, E Soriano, J Avila

Affiliation

¹ Molecular Neurobiology Department, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.

PMID: 23519405
DOI: 10.1038/mp.2013.27

No abstract available

MeSH terms

Alzheimer Disease / pathology*
Alzheimer Disease / prevention & control
Animals
Dentate Gyrus / drug effects
Dentate Gyrus / growth & development
Dentate Gyrus / pathology*
Doxycycline / pharmacology
Glycogen Synthase Kinase 3 / adverse effects*
Glycogen Synthase Kinase 3 / genetics
Glycogen Synthase Kinase 3 / metabolism
Glycogen Synthase Kinase 3 beta
Mice
Nerve Degeneration / prevention & control*
Neurogenesis / drug effects
Neurogenesis / genetics
Neuroprotective Agents / pharmacology
Phenotype
Up-Regulation / drug effects

Substances

Neuroprotective Agents
Glycogen Synthase Kinase 3 beta
Gsk3b protein, mouse
Glycogen Synthase Kinase 3
Doxycycline