Abstract
Successful derivation of pancreatic progenitors from human embryonic stem cells (hESCs) in vitro and further differentiation towards functional β cells in vivo may create the possibility of using hESC-derived pancreatic progenitors (PPs), instead of derived β cells, as an alternative transplantable source in β cell replacement therapy. Here we discuss present approaches, as well as future alternatives, in the fields of basic and clinic research on β cell differentiation, derivation and transplantation.
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors / metabolism
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CD24 Antigen / metabolism
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Cell Differentiation
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Embryonic Stem Cells / cytology*
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Humans
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Induced Pluripotent Stem Cells / cytology
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Induced Pluripotent Stem Cells / metabolism
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Insulin-Secreting Cells / cytology
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Mice
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Nerve Tissue Proteins / metabolism
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Pancreas / cytology*
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Thromboplastin / metabolism
Substances
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Basic Helix-Loop-Helix Transcription Factors
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CD24 Antigen
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NEUROG3 protein, human
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Nerve Tissue Proteins
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Thromboplastin