A splicing twist on metastasis

Sci Transl Med. 2013 Jan 23;5(169):169fs2. doi: 10.1126/scitranslmed.3005424.

Abstract

An oncogenic splice variant of the transcription factor KLF6 is associated with metastasis and poor survival in node-negative breast cancer patients and promotes the epithelial-to-mesenchymal transition by regulating Twist.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing / genetics*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy
  • Epithelial-Mesenchymal Transition / genetics
  • Female
  • Humans
  • Kruppel-Like Transcription Factors / genetics*
  • Kruppel-Like Transcription Factors / metabolism
  • Lymph Nodes / pathology
  • Lymphatic Metastasis / genetics
  • Lymphatic Metastasis / pathology
  • Molecular Targeted Therapy
  • Neoplasm Metastasis / genetics*
  • Signal Transduction / genetics
  • Tumor Microenvironment / genetics

Substances

  • Kruppel-Like Transcription Factors