Abstract
A simple method for the preparation of a highly stable and reliable surface-enhanced Raman scattering (SERS) substrate was proposed. The SERS enhancement was demonstrated with good controllability and reproducibility through the controlled formation/deformation of SERS "hotspots" using a reversible DNA nanoswitch. Highly effective DNA detection was achieved using a well-designed sandwich structure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / chemistry
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Biosensing Techniques / methods*
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DNA / chemistry*
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Disulfides / chemistry
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Fluorescence Resonance Energy Transfer / methods
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Hydrogen-Ion Concentration
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Ligands
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Materials Testing
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Metal Nanoparticles / chemistry*
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Nanoparticles / chemistry*
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Nanotechnology / methods*
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Oligonucleotides / genetics
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Silver / chemistry
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Spectrum Analysis, Raman / methods*
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Surface Properties
Substances
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Disulfides
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Ligands
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Oligonucleotides
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Silver
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Adenosine Triphosphate
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DNA