Grapefruit-medication interactions: forbidden fruit or avoidable consequences?

CMAJ. 2013 Mar 5;185(4):309-16. doi: 10.1503/cmaj.120951. Epub 2012 Nov 26.
No abstract available

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / chemically induced
  • Beverages / adverse effects*
  • Biological Availability
  • Breast Neoplasms / chemically induced
  • Citrus paradisi / adverse effects*
  • Citrus paradisi / metabolism
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 CYP3A Inhibitors*
  • Drug-Related Side Effects and Adverse Reactions*
  • Female
  • Food-Drug Interactions / physiology*
  • Fruit / adverse effects*
  • Fruit / metabolism
  • Furocoumarins / metabolism
  • Humans
  • Metabolic Detoxication, Phase I*
  • Pharmaceutical Preparations / metabolism
  • Rhabdomyolysis / chemically induced
  • Risk Factors
  • Torsades de Pointes / chemically induced

Substances

  • Cytochrome P-450 CYP3A Inhibitors
  • Furocoumarins
  • Pharmaceutical Preparations
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human