Delivery of ricin toxin a-chain by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers

Adv Healthc Mater. 2012 May;1(3):348-53. doi: 10.1002/adhm.201200022. Epub 2012 Apr 2.

Abstract

Mesoporous silica nanoparticle-supported lipid bilayers, or "protocells", exhibit a high loading capacity, enhanced colloidal stability, and peptide-directed, cell-specific uptake, making them especially well-suited for targeted delivery of protein toxins to cancer. Protocells loaded with ricin toxin A-chain (RTA) and targeted to hepatocellular carcinoma cause complete cell death at 30 pM of RTA without affecting the viability of control hepatocytes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Carcinoma, Hepatocellular / drug therapy*
  • Carcinoma, Hepatocellular / pathology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Humans
  • Lipid Bilayers / chemistry*
  • Materials Testing
  • Nanocapsules / chemistry*
  • Porosity
  • Ricin / administration & dosage*
  • Ricin / chemistry*
  • Silicon Dioxide / chemistry*

Substances

  • Lipid Bilayers
  • Nanocapsules
  • Silicon Dioxide
  • Ricin