[Role of high-dose chemotherapy followed by bone marrow autograft in the treatment of metastatic Ewing's sarcoma in children]

Bull Cancer. 1990;77(2):181-7.
[Article in French]

Abstract

Thirty-two children were treated for metastatic Ewing sarcoma by high-dose chemotherapy followed by autologous bone marrow transplantation. Fourteen patients entered phase II studies of high-dose alkylating agents. The response rate observed was 61%. High-dose chemotherapy was used as consolidation in complete remission of 18 patients. Disease free survival appears to be better than that observed under conventional altered chemotherapy. However, with only 4/18 long term survivors, these results remain unsatisfactory, taking into account the recent encouraging results of semi-continuous conventional chemotherapy.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Alkylating Agents / administration & dosage
  • Alkylating Agents / adverse effects
  • Alkylating Agents / therapeutic use*
  • Bone Marrow Transplantation*
  • Child
  • Child, Preschool
  • Combined Modality Therapy
  • Drug Evaluation
  • Female
  • Humans
  • Infant
  • Male
  • Sarcoma, Ewing / secondary*
  • Sarcoma, Ewing / therapy

Substances

  • Alkylating Agents