Abstract
Non-small cell lung carcinoma (NSCLC) metastasis and drug resistance has been associated with epithelial-to-mesenchymal transition (EMT). This study reports the development of a robust gene expression signature of EMT in NSCLC and reveals new insights into the key molecular events that underlie EMT and drug resistance in NSCLC.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Animals
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Axl Receptor Tyrosine Kinase
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Carcinoma, Non-Small-Cell Lung / genetics*
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Drug Resistance, Neoplasm / genetics*
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Epithelial-Mesenchymal Transition / genetics*
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Humans
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Lung Neoplasms / genetics*
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Protein Kinase Inhibitors / pharmacology*
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Proto-Oncogene Proteins / antagonists & inhibitors*
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Receptor Protein-Tyrosine Kinases / antagonists & inhibitors*
Substances
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Protein Kinase Inhibitors
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Proto-Oncogene Proteins
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Receptor Protein-Tyrosine Kinases
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Axl Receptor Tyrosine Kinase
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AXL protein, human