Highly enantioselective Rh-catalyzed carboacylation of olefins: efficient syntheses of chiral poly-fused rings

J Am Chem Soc. 2012 Dec 12;134(49):20005-8. doi: 10.1021/ja309978c. Epub 2012 Nov 28.

Abstract

Here we report the first highly enantioselective Rh-catalyzed carboacylation of olefins via C-C bond activation of benzocyclobutenones. Good yields and excellent enantioselectivities (92-99% ee, 14 examples) were obtained for substrates with various steric and electronic properties. In addition, fully saturated poly-fused rings were prepared from the carboacylation products through a challenging catalytic reductive dearomatization approach. These investigations provide a distinct way to prepare chiral carbon frameworks that are nontrivial to access with conventional methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acylation
  • Alkenes / chemistry*
  • Catalysis
  • Cyclization
  • Cyclobutanes / chemical synthesis*
  • Cyclobutanes / chemistry
  • Models, Molecular
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Rhodium / chemistry*
  • Stereoisomerism

Substances

  • Alkenes
  • Cyclobutanes
  • Organometallic Compounds
  • cyclobutenone
  • Rhodium