Carbamate protection of AChE against inhibition by agricultural chemicals

J Biochem Mol Toxicol. 2012 Dec;26(12):506-9. doi: 10.1002/jbt.21456. Epub 2012 Nov 20.

Abstract

The carbamate pyridostigmine bromide has been used as a pretreatment to protect individuals from the nerve agent soman. Previous research showed that pyridostigmine significantly protected human muscle acetylcholinesterase in vitro from soman and bovine red blood cell acetylcholinesterase from some organophosphorous pesticides. Research presented here demonstrates that pretreatment with other carbamates also protects acetylcholinesterase from inhibition by the pesticides chlorpyrifos-oxon and diazinon-oxon, but not from malaoxon.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Carbamates / pharmacology*
  • Cattle
  • Chlorpyrifos / analogs & derivatives
  • Chlorpyrifos / toxicity
  • Cholinesterase Inhibitors / toxicity*
  • Organophosphates / toxicity*
  • Organophosphorus Compounds / toxicity
  • Pesticides / toxicity*

Substances

  • Carbamates
  • Cholinesterase Inhibitors
  • Organophosphates
  • Organophosphorus Compounds
  • Pesticides
  • O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate
  • diazoxon
  • Chlorpyrifos