No association between TGF-β1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients

Radiother Oncol. 2012 Dec;105(3):296-8. doi: 10.1016/j.radonc.2012.09.016. Epub 2012 Nov 3.

Abstract

This study aimed at validating the previously published association between TGF-β1 single nucleotide polymorphisms and a reduced risk for radiation-induced lung toxicity. We were not able to confirm the reported association, neither using maximum dyspnea score nor after correction for baseline dyspnea score.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carcinoma, Non-Small-Cell Lung / radiotherapy
  • Cohort Studies
  • Dyspnea / etiology
  • Europe
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / radiotherapy*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Polymorphism, Single Nucleotide*
  • Radiation Pneumonitis* / genetics
  • Radiotherapy Dosage
  • Risk Factors
  • Small Cell Lung Carcinoma / genetics*
  • Small Cell Lung Carcinoma / pathology
  • Small Cell Lung Carcinoma / radiotherapy
  • Transforming Growth Factor beta1 / genetics*

Substances

  • Transforming Growth Factor beta1