Balance of DNA methylation and demethylation in cancer development

Genome Biol. 2012 Oct 23;13(10):173. doi: 10.1186/gb-2012-13-10-2012.

Abstract

Genome-wide 5-hydroxymethylome analysis of a rodent hepatocarcinogen model reveals that 5-hydroxymethylcytosine-dependent active DNA demethylation may be functionally important in the early stages of carcinogenesis.

Publication types

  • Comment

MeSH terms

  • 5-Methylcytosine / analogs & derivatives
  • Animals
  • Cytosine / analogs & derivatives*
  • Cytosine / metabolism
  • DNA Methylation / drug effects*
  • Liver / metabolism*
  • Male
  • Phenobarbital / pharmacology*

Substances

  • 5-hydroxymethylcytosine
  • 5-Methylcytosine
  • Cytosine
  • Phenobarbital