Rhodium catalyzed synthesis of isoindolinones via C-H activation of N-benzoylsulfonamides

Tetrahedron. 2012 Nov 11;68(45):9192-9199. doi: 10.1016/j.tet.2012.08.095. Epub 2012 Sep 4.

Abstract

An efficient approach to a wide range of isoindolinones, including 3-monosubstituted and 3,3-disubstituted isoindolinones, from the annulation of N-benzoylsulfonamides with olefins and diazoacetate has been developed. The transformation is broadly compatible with both terminal and internal olefins. Moreover, diazoacetate is for the first time incorporated into an amide-directed C-H functionalization reaction. Specifically, the rhodium complex [{RhCl(2)Cp*}(2)] enables the in situ dimerization of diazoacetate in addition to its role in catalyzing C-H functionalization/cross-coupling.