Histology, anatomy, or geography? Exome sequencing begins to delineate somatic mutational differences in esophageal cancer

Cancer Discov. 2012 Oct;2(10):870-1. doi: 10.1158/2159-8290.CD-12-0393.

Abstract

Esophageal carcinoma is composed of squamous cell and adenocarcinoma types, each with geographically distinct incidence. The earliest exome sequences in this disease begin to illuminate the genetic demarcations of these anatomically related cancers.

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology
  • Base Sequence
  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / pathology
  • Esophageal Neoplasms / genetics*
  • Esophageal Neoplasms / pathology
  • Exome*
  • Head and Neck Neoplasms / genetics*
  • Head and Neck Neoplasms / pathology
  • Humans
  • Mutation*
  • Receptors, Notch / genetics*
  • Sequence Analysis, DNA
  • Squamous Cell Carcinoma of Head and Neck

Substances

  • Receptors, Notch