Safety assessment of alkyl PEG ethers as used in cosmetics

Int J Toxicol. 2012 Sep-Oct;31(5 Suppl):169S-244S. doi: 10.1177/1091581812444141.

Abstract

The CIR Expert Panel assessed the safety of Alkyl PEG Ethers as used in cosmetics. These ingredients primarily function in cosmetics as surfactants, and some have additional functions as skin-conditioning agents, fragrance ingredients, and emulsion stabilizers. The Panel reviewed available relevant animal and clinical data, as well as information from previous CIR reports; when data were not available for individual ingredients, the Panel extrapolated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol repeat units.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Administration, Cutaneous
  • Alkylation
  • Animals
  • Consumer Product Safety*
  • Cosmetics / chemistry*
  • Cosmetics / toxicity
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / chemistry
  • Dermatologic Agents / pharmacokinetics
  • Dermatologic Agents / toxicity
  • Ethers / administration & dosage
  • Ethers / chemistry
  • Ethers / pharmacokinetics
  • Ethers / toxicity*
  • Humans
  • Lethal Dose 50
  • No-Observed-Adverse-Effect Level
  • Polyethylene Glycols / administration & dosage
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / pharmacokinetics
  • Polyethylene Glycols / toxicity*
  • Skin Care / adverse effects
  • Surface-Active Agents / administration & dosage
  • Surface-Active Agents / pharmacokinetics
  • Surface-Active Agents / toxicity*
  • Toxicity Tests

Substances

  • Cosmetics
  • Dermatologic Agents
  • Ethers
  • Surface-Active Agents
  • Polyethylene Glycols