Description of two novel HLA-B alleles, B*37:34 and B*44:152

Tissue Antigens. 2012 Dec;80(6):545-6. doi: 10.1111/tan.12012. Epub 2012 Oct 4.

Abstract

Two novel HLA-B alleles were characterized. HLA-B*37:34 shows two nucleotide differences regarding B*37:10 at codons 79 (CGC>CGG) and 80 (ACC>ATC), resulting in one amino acid replacement at position 80 (T>I). HLA-B*44:152 differs from B*44:02:01 in one nucleotide at codon 81 (GCG>ACG) giving rise to a leucine to threonine substitution at position 81.

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Amino Acid Substitution
  • Genotyping Techniques
  • HLA-B37 Antigen / genetics*
  • HLA-B44 Antigen / genetics*
  • Histocompatibility Testing
  • Humans
  • Molecular Sequence Data
  • Point Mutation
  • Polymorphism, Single Nucleotide
  • Sequence Homology, Amino Acid

Substances

  • HLA-B37 Antigen
  • HLA-B44 Antigen