Abstract
Purpose of review:
To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies.
Recent findings:
Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1γ, and NXP-2. Each of these is associated with a distinct clinical phenotype. Autoantibodies found in patients with autoimmune necrotizing myopathies recognize signal recognition particle and 3-hydroxy-3-methylglutaryl-coenzime A reductase (HMG-CoA) reductase. The latter are found in patients with statin-associated autoimmune muscle disease.
Summary:
As these are helpful both diagnostically and prognostically, a rheumatologist should be familiar with autoantibodies found in patients with dermatomyositis and the autoimmune necrotizing myopathies.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adenosine Triphosphatases / immunology
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Autoantibodies / blood*
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Autoantigens / immunology
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Autoimmune Diseases / blood
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Autoimmune Diseases / immunology*
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Autoimmune Diseases / pathology
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Autoimmunity*
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DEAD-box RNA Helicases / immunology
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DNA-Binding Proteins / immunology
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Dermatomyositis / chemically induced
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Dermatomyositis / immunology*
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Dermatomyositis / pathology
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Humans
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Hydroxymethylglutaryl CoA Reductases / immunology
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects
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Interferon-Induced Helicase, IFIH1
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Mi-2 Nucleosome Remodeling and Deacetylase Complex / immunology
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Necrosis
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Signal Recognition Particle / immunology
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Transcription Factors / immunology
Substances
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Autoantibodies
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Autoantigens
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CHD4 protein, human
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DNA-Binding Proteins
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Signal Recognition Particle
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TRIM33 protein, human
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Transcription Factors
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Hydroxymethylglutaryl CoA Reductases
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Mi-2 Nucleosome Remodeling and Deacetylase Complex
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Adenosine Triphosphatases
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IFIH1 protein, human
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MORC3 protein, human
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DEAD-box RNA Helicases
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Interferon-Induced Helicase, IFIH1