Treg cells, life history, and diversity

Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a007021. doi: 10.1101/cshperspect.a007021.

Abstract

Regulatory T cells expressing the FoxP3 transcription factor have a profound and nonredundant role in several aspects of immunological tolerance. We will review here the specification of this lineage, its population dynamics, and the diversity of subphenotypes that correlate with their diverse roles in controlling inflammation in a variety of settings.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Forkhead Transcription Factors / metabolism
  • Forkhead Transcription Factors / physiology
  • Humans
  • Immune Tolerance
  • Phenotype
  • T-Lymphocytes, Regulatory / cytology
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / metabolism

Substances

  • FOXP3 protein, human
  • Forkhead Transcription Factors