Auditory stream segregation impairments in schizophrenia

Abstract

We used behavior and event-related potentials (ERPs) to examine auditory stream segregation in people with schizophrenia and control participants. During each trial, a context pattern was presented, consisting of low (A) and high (B) tones and silence (-) in a repeating ABA- pattern, with a frequency separation (Δf) of 3, 6, or 12 semitones. Next, a test ABA-pattern was presented that always had a 6-semitone Δf. Larger Δf during the context resulted in more perception of two streams and larger N1 and P2 ERPs, but less perception of two streams during the test pattern. These effects of Δf were smaller in schizophrenia. Individuals with schizophrenia also showed a reduced effect of prior perceptual judgments. Overall, the findings demonstrate that people with schizophrenia have abnormalities in segregating sounds. These abnormalities result from difficulties utilizing frequency cues in addition to reduced temporal context effects.