A self-assembled delivery platform with post-production tunable release rate

J Am Chem Soc. 2012 Aug 8;134(31):12908-11. doi: 10.1021/ja3051876. Epub 2012 Jul 26.

Abstract

Self-assembly of three molecular components results in a delivery platform, the release rate of which can be tuned after its production. A fluorophore-conjugated gelator can be hydrolyzed by an enzyme, resulting in the release of a fluorescent small molecule. To allow the release to be tunable, the enzyme is entrapped in liposomes and can be liberated by heating the system for a short period. Crucially, the heating time determines the amount of enzyme liberated; with that, the release rate can be tuned by the time of heating.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoquinolines / chemistry
  • Catalysis
  • Chymotrypsin / metabolism
  • Drug Carriers / chemistry*
  • Fluorescent Dyes / chemistry
  • Gels / chemistry*
  • Hot Temperature
  • Kinetics
  • Liposomes*

Substances

  • Aminoquinolines
  • Drug Carriers
  • Fluorescent Dyes
  • Gels
  • Liposomes
  • 6-aminoquinoline
  • Chymotrypsin