Asymmetric total synthesis of cladosporin and isocladosporin

Huaiji Zheng; Changgui Zhao; Bowen Fang; Peng Jing; Juan Yang; Xingang Xie; Xuegong She

doi:10.1021/jo300805n

Asymmetric total synthesis of cladosporin and isocladosporin

J Org Chem. 2012 Jul 6;77(13):5656-63. doi: 10.1021/jo300805n. Epub 2012 Jun 11.

Authors

Huaiji Zheng¹, Changgui Zhao, Bowen Fang, Peng Jing, Juan Yang, Xingang Xie, Xuegong She

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, PR China.

PMID: 22663064
DOI: 10.1021/jo300805n

Abstract

The first asymmetric total syntheses of cladosporin and isocladosporin were accomplished in 8 steps with 8% overall yield and 10 steps with 26% overall yield, respectively. The relative configuration of isocladosporin was determined via this total synthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Isocoumarins / chemical synthesis*
Isocoumarins / chemistry
Molecular Structure
Stereoisomerism

Substances

Isocoumarins
cladosporin