Synthesis and pharmacological evaluation of new 4,4-diphenylbut-3-enyl derivatives of 4-hydroxybutanamides as GABA uptake inhibitors

Acta Pol Pharm. 2012 Jan-Feb;69(1):157-60.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticonvulsants / chemical synthesis*
  • Anticonvulsants / pharmacology*
  • GABA Plasma Membrane Transport Proteins / drug effects*
  • GABA Plasma Membrane Transport Proteins / metabolism
  • GABA Uptake Inhibitors / chemical synthesis*
  • GABA Uptake Inhibitors / pharmacology*
  • Hydroxamic Acids / chemical synthesis*
  • Hydroxamic Acids / pharmacology*
  • Mice
  • Molecular Structure
  • Structure-Activity Relationship
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Anticonvulsants
  • GABA Plasma Membrane Transport Proteins
  • GABA Uptake Inhibitors
  • Gabt4 protein, mouse
  • Hydroxamic Acids
  • Slc6a1 protein, mouse
  • Slc6a12 protein, mouse
  • Slc6a13 protein, mouse
  • gamma-Aminobutyric Acid