Cytotoxic effect of paclitaxel incorporated in nanoparticles based on lactic and glycolic acid copolymer
Bull Exp Biol Med. 2011 Jul;151(3):340-3.
doi: 10.1007/s10517-011-1325-9.
[Article in
English,
Russian]
Affiliation
- 1 Department of Pharmacology, Pharmaceutical Faculty, I. M. Setchenov Moscow Medical University, Russia. vzivkovic@mail.ru
Abstract
Paclitaxel dosage form on nanoparticles of 200-300 nm based on lactic and glycolic acid copolymer was obtained by the co-precipitation method. The possibility of controlled release of paclitaxel at pH 7.4 for 24 h was studied in vitro. Studies on Jurkat/WT human T-lymphoblastic leukemia cells showed that incorporation of paclitaxel in the nanoparticles led to a 4-fold increase of its cytotoxicity (6.8×10(-6) M) in comparison with paclitaxel solution. The efficiency of compositions containing polysorbate-80 was comparable to that of non-modified nanoparticles containing paclitaxel.
MeSH terms
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Antineoplastic Agents, Phytogenic / adverse effects
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / toxicity
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Cell Line, Tumor
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Delayed-Action Preparations / chemistry*
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Delayed-Action Preparations / pharmacology*
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Drinking Behavior / drug effects
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Drug Delivery Systems / methods*
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Glycolates / chemistry
-
Humans
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Jurkat Cells
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Lactic Acid / chemistry
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Nanoparticles / chemistry*
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Paclitaxel / adverse effects
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Paclitaxel / pharmacology*
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Paclitaxel / toxicity
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Polymers / chemistry
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Polymers / pharmacology
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Polysorbates / chemistry
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Polysorbates / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Delayed-Action Preparations
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Glycolates
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Polymers
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Polysorbates
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glycolic acid
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Lactic Acid
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Paclitaxel