A gene-based approach for testing association of rare alleles

Hongyan Xu; Varghese George

doi:10.1186/1753-6561-5-S9-S7

A gene-based approach for testing association of rare alleles

BMC Proc. 2011 Nov 29;5 Suppl 9(Suppl 9):S7. doi: 10.1186/1753-6561-5-S9-S7.

Authors

Hongyan Xu¹, Varghese George

Affiliation

¹ Department of Biostatistics, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30912, USA. hxu@georgiahealth.edu.

Abstract

Rare genetic variants have been shown to be important to the susceptibility of common human diseases. Methods for detecting association of rare genetic variants are drawing much attention. In this report, we applied a gene-based approach to the 200 simulated data sets of unrelated individuals. The test can detect the association of some genes with multiple rare variants.