Chiral Brønsted acid catalyzed enantioselective propargylation of aldehydes with allenylboronate

Org Lett. 2012 Feb 17;14(4):1142-5. doi: 10.1021/ol300075n. Epub 2012 Jan 24.

Abstract

A highly enantioselective chiral Brønsted acid catalyzed propargylation of aldehydes with allenylboronate is described. The reaction is shown to be practical and quite general with a broad substrate scope covering aryl, polyaryl, heteroaryl, α,β-unsaturated, and aliphatic aldehydes.

MeSH terms

  • Acids / chemistry
  • Aldehydes / chemistry*
  • Boronic Acids / chemistry*
  • Catalysis
  • Molecular Structure
  • Stereoisomerism

Substances

  • Acids
  • Aldehydes
  • Boronic Acids