The RNA component of RNase P in Schizosaccharomyces species

FEBS Lett. 1990 Oct 1;271(1-2):189-93. doi: 10.1016/0014-5793(90)80403-6.

Abstract

In the fission yeast Schizosaccharomyces pombe, the enzyme RNAse P copurifies with two RNAs, K1- and K2-RNA, which are identical except for their termini [1] and which are encoded by a single gene [2]. We have undertaken the cloning of the K-RNA genes in related organisms in order to gain comparative structural information. Because the K-RNA sequence is poorly conserved across species, we have cloned the K-RNA genes in the Schizosaccharomyces species S. malidevorans, S. japonicus, S. versatilis, and S. octosporus. Of the 4 species, only S. octosporus contains a K-RNA gene different from that in S. pombe; the gene diverges by 20%. Based on the two sequences, nuclease protection data and computer analysis, we have proposed a secondary structure model for the K-RNA. Northern analysis shows the K-RNA genes in all four Schizosaccharomyces species to be expressed as two RNAs, as in S. pombe.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • Endoribonucleases / chemistry*
  • Endoribonucleases / genetics
  • Genes, Fungal*
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Phylogeny
  • RNA Probes
  • RNA, Fungal / chemistry*
  • Ribonuclease P
  • Schizosaccharomyces / enzymology
  • Schizosaccharomyces / genetics*

Substances

  • RNA Probes
  • RNA, Fungal
  • Endoribonucleases
  • Ribonuclease P

Associated data

  • GENBANK/X52530
  • GENBANK/X52531