A rare cryptic and complex rearrangement leading to MLL-MLLT10 gene fusion masked by del(10)(p12) in a child with acute monoblastic leukemia (AML-M5)

Leuk Res. 2012 Apr;36(4):e74-7. doi: 10.1016/j.leukres.2011.12.009. Epub 2012 Jan 18.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormal Karyotype
  • Base Sequence
  • Chromosomes, Artificial, Bacterial
  • Chromosomes, Human, Pair 10 / genetics*
  • Chromosomes, Human, Pair 11 / genetics*
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Infant
  • Leukemia, Monocytic, Acute / genetics*
  • Male
  • Molecular Sequence Data
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Recombinant Fusion Proteins / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription Factors / genetics*

Substances

  • KMT2A protein, human
  • MLLT10 protein, human
  • Recombinant Fusion Proteins
  • Transcription Factors
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase