Parallel independent component analysis using an optimized neurovascular coupling for concurrent EEG-fMRI sources

Annu Int Conf IEEE Eng Med Biol Soc. 2011:2011:2542-5. doi: 10.1109/IEMBS.2011.6090703.

Abstract

The complexity of the human brain and the limitation of any one imaging approach motivates the need for multimodal measurements to better understand cerebral processing. A very natural goal is to integrate electrophysiological and hemodynamic activity. Among them, concurrent EEG-fMRI studies have shown great promise for understanding intrinsic brain properties yet analyzing such data presents a significant methodological challenge. Here, we propose a multivariate parallel ICA decomposition incorporating dynamic neurovascular coupling for concurrent EEG-fMRI recordings. The goal of our algorithm is to fuse multimodal EEG-fMRI information and detect/interpret the relationship between electrophysiological and hemodynamic sources via a temporal neurovascular connection enhancement. We analyze the performance of the algorithm on a valid simulation based on real EEG and fMRI components (sources) from our previous works and a neurovascular coupling built from an extended 'balloon model'. The results from our simulations yield an accurate source tracking and linkage for concurrent EEG-fMRI, and provide a novel and efficient way to combine EEG and hemodynamic responses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Cerebral Cortex / blood supply*
  • Electroencephalography / methods*
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Multivariate Analysis
  • Principal Component Analysis