Near infrared spectroscopy for the detection of desaturations in vulnerable ischemic brain tissue: a pilot study at the stroke unit bedside

Stroke. 2012 Apr;43(4):1134-6. doi: 10.1161/STROKEAHA.111.636894. Epub 2011 Dec 22.

Abstract

Background and purpose: There is uncertainty whether bilateral near infrared spectroscopy (NIRS) can be used for monitoring of patients with acute stroke.

Methods: The NIRS responsiveness to systemic and stroke-related changes was studied overnight by assessing the effects of brief peripheral arterial oxygenation and mean arterial pressure alterations in the affected versus nonaffected hemisphere in 9 patients with acute stroke.

Results: Significantly more NIRS drops were registered in the affected compared with the nonaffected hemisphere (477 drops versus 184, P<0.001). In the affected hemispheres, nearly all peripheral arterial oxygenation drops (n=128; 96%) were detected by NIRS; in the nonaffected hemispheres only 23% (n=30; P=0.17). Only a few mean arterial pressure drops were followed by a significant NIRS drop. This was however significantly different between both hemispheres (32% versus 13%, P=0.01).

Conclusions: This pilot study found good responsiveness of NIRS signal to systemic and stroke-related changes at the bedside but requires confirmation in a larger sample.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Blood Pressure
  • Brain / metabolism*
  • Brain / physiopathology
  • Brain Ischemia / metabolism*
  • Brain Ischemia / physiopathology
  • Cerebral Arteries / metabolism*
  • Cerebral Arteries / physiopathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oxygen / metabolism*
  • Spectrophotometry, Infrared / methods
  • Stroke / metabolism*
  • Stroke / physiopathology

Substances

  • Oxygen