Short- and long-term immunological and virological outcome in HIV-infected infants according to the age at antiretroviral treatment initiation

Clin Infect Dis. 2012 Mar;54(6):878-81. doi: 10.1093/cid/cir950. Epub 2011 Dec 23.

Abstract

The clinical benefit of antiretroviral therapy in infants is established. In this cohort collaboration, we compare immunological and virological response to treatment started before or after 3 months of age. Early initiation provides a better short-term response, although evolution after 12 months of age is similar in both groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Anti-HIV Agents / therapeutic use*
  • CD4 Lymphocyte Count
  • HIV Infections / drug therapy*
  • HIV Infections / immunology*
  • Humans
  • Infant
  • Kaplan-Meier Estimate
  • Monte Carlo Method
  • Proportional Hazards Models
  • Statistics, Nonparametric
  • Time Factors
  • Viral Load*

Substances

  • Anti-HIV Agents