Supramolecular host-guest interaction for labeling and detection of cellular biomarkers

Angew Chem Int Ed Engl. 2012 Jan 9;51(2):450-4. doi: 10.1002/anie.201105670. Epub 2011 Nov 24.

Abstract

Be my guest: A supramolecular host-guest interaction is utilized for highly efficient bioorthogonal labeling of cellular targets. Antibodies labeled with a cyclodextrin host molecule bind to adamantane-labeled magnetofluorescent nanoparticles (see picture) and provide an amplifiable strategy for biomarker detection that can be adapted to different diagnostic techniques such as molecular profiling or magnetic cell sorting.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adamantane / chemistry*
  • Animals
  • Antibodies / analysis*
  • Antibodies / chemistry
  • Biomarkers / analysis
  • Cell Line
  • Cyclodextrins / chemistry*
  • Fluorescent Dyes / analysis*
  • Fluorescent Dyes / chemistry
  • Humans
  • Nanoparticles / analysis*
  • Nanoparticles / chemistry

Substances

  • Antibodies
  • Biomarkers
  • Cyclodextrins
  • Fluorescent Dyes
  • Adamantane