Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate

Angew Chem Int Ed Engl. 2012 Jan 9;51(2):445-9. doi: 10.1002/anie.201105565. Epub 2011 Nov 23.

Abstract

Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a Zn(II)-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cell Line, Tumor
  • Humans
  • Mice
  • Nanoconjugates / chemistry*
  • Neoplasms / genetics
  • Organometallic Compounds / chemistry*
  • Picolines / chemistry*
  • RNA Interference*
  • RNA, Small Interfering / administration & dosage*
  • RNA, Small Interfering / genetics

Substances

  • Nanoconjugates
  • Organometallic Compounds
  • Picolines
  • RNA, Small Interfering
  • zinc(II) dipicolylamine