Abstract
In continuation of our work on Indian celery (Seseli diffusum (Roxb. ex Sm.) Santapau & Wagh; Umbelliferae), the fractionation of the 80% MeOH-H(2) O extract of the seeds was performed to identify the principles responsible for its folk use as an antispasmodic and diuretic. Several compounds were isolated as active components: seselin (1) and anthriscinol methyl ether (4) showed a selective cytotoxicity to some yeast strains. Compound 1 also showed spasmolytic activity. On the other hand, isopimpinellin (3) and isorutarin (5) exhibited a spasmogenic effect on the smooth muscle preparations. Compound 5 was also found to have antioxidant activity. Among them, compound 4 was isolated for the first time from this plant.
Copyright © 2011 John Wiley & Sons, Ltd.
MeSH terms
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Apiaceae / chemistry*
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Benzodioxoles / chemistry
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Benzodioxoles / isolation & purification
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Benzodioxoles / pharmacology
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Cell Survival / drug effects
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Coumarins / chemistry
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Coumarins / isolation & purification
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Coumarins / pharmacology
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Diuretics / chemistry
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Diuretics / isolation & purification
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Diuretics / pharmacology*
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Furocoumarins / chemistry
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Furocoumarins / isolation & purification
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Furocoumarins / pharmacology
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
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Muscle, Smooth / physiology
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Parasympatholytics / chemistry
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Parasympatholytics / isolation & purification
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Parasympatholytics / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Seeds / chemistry*
Substances
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Antioxidants
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Benzodioxoles
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Coumarins
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Diuretics
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Furocoumarins
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Parasympatholytics
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Plant Extracts
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anthriscinol methyl ether
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isopimpinellin
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seselin