Romiplostim efficacy in an acute myeloid leukemia patient with transfusion refractory thrombocytopenia

Transfusion. 2012 Apr;52(4):739-41. doi: 10.1111/j.1537-2995.2011.03382.x. Epub 2011 Nov 14.

Abstract

Background: Refractoriness to platelet (PLT) transfusion is a feared, life-threatening complication in hematology-oncology patients. Despite increased PLT requirement and treatment costs, the clinical management is difficult and these patients had less favorable outcomes.

Case report: We report on the efficacy of the thrombopoietic agent romiplostim in a patient with acute myeloid leukemia with chemotherapy-induced transfusion-refractory thrombocytopenia.

Conclusion: Romiplostim could be very helpfull in the management of AML patients with transfusion refractory thrombocytopenia.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy*
  • Middle Aged
  • Platelet Transfusion*
  • Receptors, Fc / therapeutic use*
  • Receptors, Thrombopoietin / agonists*
  • Recombinant Fusion Proteins / therapeutic use*
  • Thrombocytopenia / drug therapy*
  • Thrombopoietin / therapeutic use*

Substances

  • Receptors, Fc
  • Receptors, Thrombopoietin
  • Recombinant Fusion Proteins
  • Thrombopoietin
  • romiplostim