Abstract
A growth-promoting activity released from activated platelets, the platelet-derived growth factor, was discovered and characterized while the cellular and molecular mechanisms underlying the formation of the lesions of atherosclerosis were being investigated. This review provides a personal account of the different challenges we faced 3 decades ago in this undertaking and describes how our path was influenced by our focus on a disease process and by the evolving general understanding of the molecular effectors of cell proliferation.
Publication types
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Historical Article
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Cell Proliferation
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History, 20th Century
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Humans
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Muscle, Smooth, Vascular / pathology
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Muscle, Smooth, Vascular / physiopathology
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Platelet-Derived Growth Factor / history*
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Platelet-Derived Growth Factor / physiology*
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Protein-Tyrosine Kinases / physiology
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Receptors, Platelet-Derived Growth Factor / physiology
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Vascular Diseases / pathology
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Vascular Diseases / physiopathology*
Substances
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Platelet-Derived Growth Factor
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Protein-Tyrosine Kinases
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Receptors, Platelet-Derived Growth Factor