Lipid metabolism and HCV infection

Paul Targett-Adams; Steeve Boulant; Mark W Douglas; John McLauchlan

doi:10.3390/v2051195

Lipid metabolism and HCV infection

Viruses. 2010 May;2(5):1195-1217. doi: 10.3390/v2051195. Epub 2010 May 11.

Authors

Paul Targett-Adams¹, Steeve Boulant², Mark W Douglas³, John McLauchlan⁴

Affiliations

¹ Pfizer Global Research & Development, Infectious Diseases Group, Sandwich Laboratories, Sandwich, CT13 9NJ, UK.
² Immune Disease Institute, Harvard Medical School, Department of Microbiology and Molecular Genetics, Boston, MA 02115, USA.
³ Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, PO Box 412, Westmead, NSW 2145, Australia.
⁴ MRC Virology Unit, Church Street, Glasgow G11 5JR, UK.

Abstract

Chronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body. A number of pathologies have been linked to the impact of HCV infection on liver metabolism. However, there is also growing evidence that hepatic metabolic processes contribute to the HCV life cycle. This review summarizes the relationship between lipid metabolism and key stages in the production of infectious HCV.

Keywords: HCV; RNA replication; VLDL assembly; cholesterol biosynthesis; fatty acid biosynthesis; hepatitis C virus; lipid droplets; lipid metabolism; virus assembly.

Abstract

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