Combined pallidal and subthalamic nucleus stimulation in sporadic dystonia-parkinsonism

J Neurosurg. 2012 Jan;116(1):95-8. doi: 10.3171/2011.8.JNS101552. Epub 2011 Sep 16.

Abstract

Multifocal deep brain stimulation (DBS) is a new technique that has been introduced recently. A 39-year-old man with dystonia-parkinsonism underwent the simultaneous implantation of subthalamic nucleus (STN) and globus pallidus internus (GPi) DBS electrodes. While bilateral STN DBS controlled the parkinsonian symptoms well and allowed for a reduction in levodopa, the improvement of dystonia was only temporary. Additional GPi DBS also alleviated dystonic symptoms. Formal assessment at the 1-year follow-up showed that both the parkinsonian symptoms and the dystonia were markedly improved via continuous bilateral combined STN and GPi stimulation. Sustained benefit was achieved at 3 years postoperatively.

Publication types

  • Case Reports

MeSH terms

  • Deep Brain Stimulation / methods*
  • Dystonia / physiopathology
  • Dystonia / therapy*
  • Dystonic Disorders / physiopathology
  • Dystonic Disorders / therapy*
  • Globus Pallidus / physiopathology*
  • Humans
  • Male
  • Parkinsonian Disorders / physiopathology
  • Parkinsonian Disorders / therapy*
  • Subthalamic Nucleus / physiopathology*
  • Treatment Outcome