Successful use of hirudin during cardiac surgery using minimized extracorporeal circulation in patients with heparin-induced thrombocytopenia

Assad Haneya; Alois Philipp; Karla Lehle; Claudius Diez; Leopold Rupprecht; Reinhard Kobuch; Stephan W Hirt; York A Zausig; Christof Schmid; Thomas Puehler

doi:10.1016/j.athoracsur.2011.01.032

Successful use of hirudin during cardiac surgery using minimized extracorporeal circulation in patients with heparin-induced thrombocytopenia

Ann Thorac Surg. 2011 Aug;92(2):724-6. doi: 10.1016/j.athoracsur.2011.01.032.

Authors

Assad Haneya¹, Alois Philipp, Karla Lehle, Claudius Diez, Leopold Rupprecht, Reinhard Kobuch, Stephan W Hirt, York A Zausig, Christof Schmid, Thomas Puehler

Affiliation

¹ Department of Cardiothoracic Surgery, Medical Center University Regensburg, Regensburg, Germany. assadhaneya@web.de

PMID: 21801930
DOI: 10.1016/j.athoracsur.2011.01.032

Abstract

In this case series, we describe our successful use of a reduced hirudin dosage as an anticoagulant during cardiac surgery using minimized extracorporeal circulation in patients with heparin-induced thrombocytopenia.

MeSH terms

Aged
Anticoagulants / adverse effects*
Blood Loss, Surgical / prevention & control
Blood Transfusion, Autologous
Coronary Artery Bypass / methods*
Erythrocyte Transfusion
Extracorporeal Circulation / instrumentation*
Female
Fibrinolytic Agents / administration & dosage*
Fibrinolytic Agents / blood
Heparin / adverse effects*
Hirudins / administration & dosage*
Hirudins / blood
Humans
Male
Middle Aged
Monitoring, Intraoperative
Partial Thromboplastin Time
Plasma
Postoperative Care
Recombinant Proteins / administration & dosage
Recombinant Proteins / blood
Thrombocytopenia / blood
Thrombocytopenia / chemically induced*
Whole Blood Coagulation Time

Substances

Anticoagulants
Fibrinolytic Agents
Hirudins
Recombinant Proteins
Heparin
lepirudin