Eosinophilic pustular folliculitis (Ofuji's disease) without macroscopic pustules

Int J Dermatol. 2012 Jan;51(1):50-2. doi: 10.1111/j.1365-4632.2011.04934.x. Epub 2011 Jul 26.

Abstract

Background: Eosinophilic pustular folliculitis (EPF), first described by Ofuji et al. in 1970, is a rare dermatosis characterized by pruritic papules and pustules on circinate erythematous plaques with eosinophilic infiltration in and around the hair follicle.

Methods and results: We report three cases of EPF that showed no macroscopic pustules during the total observation period. Histopathological examination revealed eosinophilic infiltration in and around the hair follicle in the lower dermis and subcutis.

Conclusions: EPF consists of clinical variants, one of which lacks obvious pustules.

MeSH terms

  • Adult
  • Dermatologic Agents / therapeutic use
  • Eosinophilia / drug therapy
  • Eosinophilia / pathology*
  • Female
  • Folliculitis / drug therapy
  • Folliculitis / pathology*
  • Humans
  • Indomethacin / therapeutic use
  • Middle Aged
  • Skin Diseases, Vesiculobullous / drug therapy
  • Skin Diseases, Vesiculobullous / pathology*
  • Tacrolimus / therapeutic use
  • Treatment Outcome

Substances

  • Dermatologic Agents
  • Tacrolimus
  • Indomethacin

Supplementary concepts

  • Eosinophilic pustular folliculitis