Nodular Lymphocyte Predominant Hodgkin's Lymphoma Presenting as Severe Hypercalcaemia: A Case Report

Ikram A Burney; V Nirmala; Mansour S Al-Moundhri; Nicholas J Woodhouse

Nodular Lymphocyte Predominant Hodgkin's Lymphoma Presenting as Severe Hypercalcaemia: A Case Report

Sultan Qaboos Univ Med J. 2007 Dec;7(3):247-51.

Authors

Ikram A Burney¹, V Nirmala, Mansour S Al-Moundhri, Nicholas J Woodhouse

Affiliation

¹ Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, P. O. Box 35, Al-Khod 123, Sultanate of Oman;

PMID: 21748111
PMCID: PMC3074891

Abstract

Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a recently described type of Hodgkin's lymphoma (HL) and accounts for 5-6% of all the cases of HL. Here we report the case of an elderly man who presented to Sultan Qaboos University Hospital, Oman, with severe hypercalcemia, and was diagnosed to have stage IV NLPHL. Although the incidence of hypercalcemia is estimated to be between 1-5% in classical HL, to our knowledge this is the first report of NLPHL presenting with severe hypercalcemia. The patient responded to the anti-CD20 monoclonal antibody, Rituximab, and has been in clinical remission for more than 3 years.

Keywords: Case Report; Hodgkin’s Lymphoma; Hypercalcemia; Monoclonal antibody; Oman; Rituximab; Thrombocytopenia.