5'-Azacitidine for therapy-related myelodysplastic syndromes after non-Hodgkin lymphoma treatment

Leuk Res. 2011 Oct;35(10):1409-11. doi: 10.1016/j.leukres.2011.05.030. Epub 2011 Jun 15.

Abstract

Therapy-related myelodysplastic syndromes are possible complications in patients treated for previous hematologic malignancies. Therapeutic strategies in these type of disorders are still not well defined: azacitidine has been recently approved for the treatment of higher risk myelodysplastic syndromes, but few data are published relating possible efficacy in therapy-related dysplastic disorders. We reported here 4 patients treated with azacitidine for therapy related dysplasia after chemotherapy for non-Hodgkin lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Azacitidine / administration & dosage
  • Azacitidine / therapeutic use*
  • Female
  • Humans
  • Lymphoma, Non-Hodgkin / drug therapy*
  • Lymphoma, Non-Hodgkin / pathology
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes / chemically induced
  • Myelodysplastic Syndromes / drug therapy*

Substances

  • Antimetabolites, Antineoplastic
  • Azacitidine