Age related changes in the myelinated fibers of corpus callosum

Qiang Xu; Wei Lu; Xuan Qiu; Shu Yang; Chen Li; Wei Zhang; Yong Tang

doi:10.1016/j.neulet.2011.05.229

Age related changes in the myelinated fibers of corpus callosum

Neurosci Lett. 2011 Jul 25;499(3):208-12. doi: 10.1016/j.neulet.2011.05.229. Epub 2011 Jun 6.

Authors

Qiang Xu¹, Wei Lu, Xuan Qiu, Shu Yang, Chen Li, Wei Zhang, Yong Tang

Affiliation

¹ Department of Histology and Embryology, Chongqing Medical University, Chongqing, PR China.

PMID: 21669252
DOI: 10.1016/j.neulet.2011.05.229

Abstract

Efficient and unbiased stereological methods were used to study the age-related changes of corpus callosum and the age-related changes of the myelinated fibers in the corpus callosum. There existed age-related atrophy of rat corpus callosum. The total volume of the myelinated fibers and the total volume of the myelin sheathes in the corpus callosum of aged rat were significantly decreased when compared to young rat. The age-related changes of corpus callosum were primarily due to the loss of the myelinated fibers with small diameters.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aging / pathology*
Animals
Atrophy / pathology
Corpus Callosum / pathology*
Female
Nerve Fibers, Myelinated / pathology*
Rats
Rats, Long-Evans