Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat

YiXiong Heng; Peck Gee Seah; Jie Yee Siew; Hui Chien Tay; Amit Singhal; Vanessa Mathys; Mehdi Kiass; Pablo Bifani; Véronique Dartois; Maxime Hervé

doi:10.1016/j.tube.2011.05.003

Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat

Tuberculosis (Edinb). 2011 Jul;91(4):339-41. doi: 10.1016/j.tube.2011.05.003. Epub 2011 Jun 1.

Authors

YiXiong Heng¹, Peck Gee Seah, Jie Yee Siew, Hui Chien Tay, Amit Singhal, Vanessa Mathys, Mehdi Kiass, Pablo Bifani, Véronique Dartois, Maxime Hervé

Affiliation

¹ Novartis Institute for Tropical Diseases, #05-01 Chromos, 10 Biopolis road, Singapore 138670, Singapore. Yixiong_heng@immunol.a-star.edu.sg

PMID: 21636324
DOI: 10.1016/j.tube.2011.05.003

Abstract

Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal
Female
Granuloma / microbiology*
Hypoxia / pathology*
Immunohistochemistry
Lung / microbiology
Lung / pathology*
Mycobacterium tuberculosis / pathogenicity*
Nitroimidazoles / pharmacology*
Rats
Tuberculosis, Pulmonary / pathology*

Substances

Nitroimidazoles
pimonidazole