The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease

Angew Chem Int Ed Engl. 2011 Jun 20;50(26):5889-91. doi: 10.1002/anie.201101740. Epub 2011 May 11.
No abstract available

MeSH terms

  • Antitubercular Agents / chemistry*
  • Antitubercular Agents / pharmacology
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / metabolism
  • Heat-Shock Proteins / chemistry*
  • Heat-Shock Proteins / metabolism
  • Mycobacterium tuberculosis / drug effects*
  • Oligopeptides / chemistry*
  • Oligopeptides / pharmacology
  • Protein Binding

Substances

  • Antitubercular Agents
  • Bacterial Proteins
  • ClpC1 protein, Mycobacterium tuberculosis
  • Heat-Shock Proteins
  • Oligopeptides
  • cyclomarin A